Lexie spies on Webber who is announcing the doctor who will be doing the next surgery solo. A series of interns run in and say that Webber said who the next surgeon would be. The interns all say different names, angering the doctors. Bailey suggests that they just use the Secret and will their name to be called. Lexie then runs in and says that Webber told her who the next surgeon is and points to who he said.

Webber gathers the doctors and tells them that the person chosen for the solo surgery is purely based on trust. He says that everyone picked Dr. Yang, but since she is out of the running she will be the one to pick the next surgeon. He adds that since Yang's interns are banned too, Yang will pick a second doctor to assist.

The doctors all try to flatter Cristina to gain her favor. She tells them all to leave her alone while she thinks about it. George and Alex talk to Izzy, but when she replies she also adds comments to Denny who is still haunting her.

Lexie goes to Sloan and tells him that she would like to learn. She makes a joke about sex and Sloan becomes angry. He says that he is her superior and she says she just wants to learn medicine, the sex was just a joke.

Lexie, Bailey and Sloan meet with their patient who needs a new voice box. Sloan tells the patient's husband what will be happening with the procedure. He asks if there are any questions and the patient holds up a post it note that says No.

Two sisters are brought in to the hospital and they are fighting loudly. The younger sister, Emma, tells on the older sister, Holly, for crashing a car when she wasn't even supposed to be driving. Callie tries to call their parents while the girls continue to fight.

George tells Cristina he's grown a lot since he started. He tells her that is the key to why he is the best choice for the surgery. Cristina says thank you and continues brushing her teeth.

Callie and Meredith attend to the girls. Alex walks in and looks at the Holly's eyes. He thinks that she may have a skull fracture. They take her away and Emma says she hopes she dies.

Izzy sees the clinic is locked and tells everyone she will be back with the keys. She leaves with Denny and talks to him. George watches Izzy talking to an imaginary person as she walks away.

Cristina meets with Dixon. She asks Cristina if she can help with the amputation. Cristina says that she has to chose one of her peers to do the surgery.

Lexie asks her patient's husband if they can fill out some forms. Lexie says that their system of communication seems to work out well for them. He tells Lexie that the post it notes are not a good system.

Callie and Sadie closely examine Holly's x-rays. Sadie brushes up against Callie and Callie stumbles away nervously.

Derek and Sloan see that Holly is crashing. Emma sees Holly is in trouble and asks what the doctors did to her. Meredith tells Emma that Holly is going into surgery. Emma is upset that the last thing she said to her sister was she hoped she died. Meredith tells her she will get an update for her.

The doctors have Holly's skull opened up and she starts to crash. He brain changes color and they wonder what went wrong. Holly dies and Dixon explains that there was nothing they could have done. Dixon says that since Holly was young, she will make an excellent candidate for organ donation.

Callie goes to Sloan, concerned about the signals that she received from Sadie. He asks if there were other signs and Callie realizes she made up the affection. He yells at her, saying she should not sleep with the interns. Later, Sadie tells Callie her necklace is beautiful. Callie says thanks then leaves.

Lexie looks over Sloan's shoulder and asks what he is working on. He yells at her for being in his space. Bailey tells Lexie to go do something else.